This 3.5 hour, in-depth course guides attendees through an understanding of Hepatitis C trends in the US, treatment options, and supporting the needs of people experiencing homelessness and/or using substances who are interested in treating their hepatitis C. Attendees will hear from people with lived expertise, clinicians, and experts in the field of hepatitis C and will learn about integrating hepatitis C treatment into primary care, providing hepatitis C treatment across health care for the homeless settings, and supporting successful treatment outcomes for people with complex medical and behavioral health care needs. A Hepatitis C Treatment Pocket Guide is available for download along with the course content.